Since the first season, many characters have left the show or have been written out, and new main characters have been written in and out of the series.
Following is a list of characters who have appeared over the various seasons since the drama's premiere.
Miranda has been given the nickname "BCB" ("Booty Call Bailey"), due to her increasing love for Ben. In Season 10, Ben talks to Shepherd about how he suspects that Bailey has OCD.
Shepherd takes this to Hunt and Bailey is forced to be followed around by an occupational therapist to help her get control of her OCD. Owen Hunt is the Chief of Surgery at Grey Sloan Memorial Hospital.
He initially moves to Seattle from New York City to get away from his adulterous ex-wife Addison Montgomery, whom he discovered was having an affair with his best friend, Mark Sloan.
He subsequently begins a long romance with Meredith Grey, which results in their marriage.
In Season 8, she is dating an anesthesiologist, Ben Warren, who proposes to her and she accepts.
He resigns after nearly dying from being shot because he thinks being Chief isn't his place.
He and Meredith adopt an orphan named Zola from Africa in Season 7.
After surviving the plane crash in the Season 8 finale, he begins Season 9 recovering from his injured hand.
His hand goes numb while he tries to grip one of the instruments before surgery. In season 10 Derek starts to work with the president, using his technology that he and Callie created.