Among these are antidepressants, antipsychotics, anticonvulsants, and antihistamines (as antiallergens, anti-motion sickness drugs, antipruritics, and hypnotics/sedatives) of the dibenzazepine, dibenzocycloheptene, dibenzothiazepine, dibenzothiepin, phenothiazine, and thioxanthene chemical classes, and others.This page is based on a Wikipedia article written by contributors (read/edit).A substantial proportion of depressed patients receive antidepressants, mostly selective serotonin reuptake inhibitors (SSRIs).Some of these have been linked to decreased BMD (SSRIs) and increased fracture risk (SSRIs and tricyclic agents).First, the presence of depression itself increases fracture risk, in relation with decreased BMD and an increase in falls.
All meds capable of changing the brain chemicals, react different in different people.
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The body of evidence suggests that SSRIs should be considered in the list of medications that are risk factors for osteoporotic fractures.► Current use of selective serotonin reuptake inhibitors (SSRIs) and tricyclics increases fracture risk.
► The increase in risk is the greatest in the early stages of treatment.