"The pathology of recurrent disease and the concerns regarding chronic inflammation again support the goal of protecting against primary infection; such protection would prevent latent seeding of the sensory ganglia and subsequent recurrent corneal disease," wrote Chris L. D., LSU Health Sciences Center, Department of Medicine, Section of Infectious Diseases, New Orleans; and Richard B. D., Department of Pediatrics, University of Texas Medical Branch at Galveston. Mc Gowin and Pyles received research support from the Gulf South STI/Topical Microbicides Cooperative Research Center.
Determining the type of HSV present in the eye and then treating that specific disease appropriately while avoiding additional flares and visual damage can be perplexing, said Edward J. D., professor of ophthalmology, University of Cincinnati, and director, Cornea Service, Cincinnati Eye Institute, Cincinnati.
Genital herpes simplex virus (HSV) infections are common, despite the availability of antiviral drugs that can treat and suppress HSV infection .
Therefore, the development of HSV vaccines is a high priority.
Women reported symptoms more frequently than did men, but preexisting immunity had little effect.
The vaccine induced higher titers of HSV g D antibody on enzyme-linked immunosorbent assays than did natural infection with HSV.